Several studies reported a deregulation of the expression of BDNF by alterations of DNA methylation and non-coding RNA in different neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS) [54,55]. This evidence concerns the gene BDNF and amyotrophic lateral sclerosis.