In CLL-derived T-cells, an impaired induction of activation markers CD25 and CD71 and impaired induction of glucose uptake and glycolysis was observed, while in BCR/ABL+ B cell lymphoblastic leukemia-derived T-cells, glucose uptake and expression of GLUT1 and HK2 was impaired after in vitro stimulation [91]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.