By contrast, after the intervention of siRNA‐FSP1 or specific inhibitors, as the expression of RAGE decreased, the expression of JAK2, STAT3, Wnt3a and β‐catenin also synchronously reduced (Figures 5, 6, 7), indicating that a crosstalk emerges among RAGE, JAK2/STAT3 and Wnt3a/β‐catenin pathways in the signal transduction of AF growth. The gene discussed is S100A4; the disease is atrial fibrillation.