In our study, DYRK1A siRNA could inhibit the expression of STAT3 and indirectly suppress the expression of p‐STAT3Tyr705, indicating that DYRK1A suppression may firstly inhibit the expression of STAT3 and then affect the expression of EGFR and Met in EGFR wild‐type NSCLC cells. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.