Meanwhile, DYRK1A suppression by siRNA distinctly down‐regulated the levels of STAT3 and indirectly suppressed p‐STAT3Tyr705 in the nuclear extractions of NCI‐H460 or A549 cells, indicating that DYRK1A positively regulates STAT3 in NSCLC cells (Figure 2C). This evidence concerns the gene STAT3 and non-small cell lung carcinoma.