In contrast, a number of non-hematopoietic cancer cell lines examined, including NCI-H441 (non-small cell lung carcinoma), JHH-1 (hepatocellular carcinoma), and A2058 (melanoma), did not display appreciable IRE1 cleavage upon ER stress (data not shown). The gene discussed is ERN1; the disease is hematopoietic and lymphoid cell neoplasm.