Overall, Fig. 4f show that sEVs derived from signature 1-associated LN18 and U87 GBM cells display similar levels of CD63, HSP70, and Annexin A2 while sharing the highest expression of CD63 and CD9 with signature 4 (U118 cells), as compared to sEVs derived from G166 and GS090 stem cells. The gene discussed is ANXA2; the disease is glioblastoma.