We performed a sub-group analysis by SVR status: patients treated with DAAs who achieved SVR developed HCC at a rate of 3.57 per 100py (95%CI: 1.63, 5.88) while the IFN-treated SVR group had a lower estimated incidence rate of 0.70/100py, (95%CI: 0.41, 1.04). This evidence concerns the gene IFNA1 and hepatocellular carcinoma.