INS and Insulin resistance: Analogously, prediabetic and metabolic symptoms such as insulin resistance are often experienced by astronauts during their missions.33,34 Thus, it would be interesting to further investigate the metabolic changes that are induced in our model, including skeletal muscle insulin-resistance, mitochondrial respiration and overall energy homeostasis, to determine if these mechanisms, which are known to impact the muscle tissue, contribute to the shift in myofiber type or are a consequence of it.