Here, we describe a method how to (1) express recombinant IL-6-HaloTag®-ORs in the neuroblastoma X glioma hybrid cell line NxG 108CC15 [20], (2) measure cell surface expression of fluorophore-labelled IL-6-HaloTag®-ORs by flow cytometry, and (3) measure odorant/OR-induced cAMP signaling in these cells, using the GloSensor® assay. The gene discussed is IL6; the disease is central nervous system cancer.