Indeed, in PNH and aplastic anemia, in addition to JAK2, TET2 and HMGA2 (mentioned above), mutations in ASXL1, DNMT3a, BCOR, BCORL1, SUZ12, and U2AF1 have been reported [39–41]. Here, ASXL1 is linked to paroxysmal nocturnal hemoglobinuria.