We evaluated the intracellular expression of p62 in oral leukoplakia tissue specimens and compared various clinical characteristics, such as the intracellular expression of p62 and dysplasia in the oral epithelium, as well as other biomarkers including 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), Ki67, and p53 associated with oral leukoplakia. The gene discussed is SQSTM1; the disease is leukoplakia.