RHOA and cancer: As podoplanin often is expressed in the invasive front of tumours, it is thought to have a role in epithelial mesenchymal transition, invasion, and metastasis (Deepa et al., 2017) However, the podoplanin‐expressing cancer cells often also express E‐cadherin and migrate in a collective manner, suggesting that there are podoplanin‐induced alternative pathways for the actin skeleton rearrangement independent of the RhoA activation and epithelial mesenchymal transition.