Besides, podoplanin has been reported to be a marker of myoepithelial cells in salivary gland tumours, and its expression may thus indicate that myoepithelial differentiation is required for tumour cells in their modulation of extracellular matrix in order to survive in poorly vascularized and hypoxic stroma (Tsuneki et al., 2013). The gene discussed is PDPN; the disease is neoplasm.