Besides, podoplanin has been reported to be a marker of myoepithelial cells in salivary gland tumours, and its expression may indicate that myoepithelial differentiation is required for tumour cells in their modulation of the extracellular matrix in order to survive in poorly vascularized and hypoxic stroma (Tsuneki et al., 2013). This evidence concerns the gene PDPN and neoplasm.