Utilizing two promising conditions, C2 and C12, AT2 organoids were grown, dissociated, and transplanted into influenza-injured recipient mice 11 days post infection (DPI) as previously described.3 Immunostaining of recipient lungs 13 days post transplant (DPT, 24 DPI) revealed that engraftments could adopt two distinct fates (Fig. 2a): maintenance of the AT2 lineage (SPC and Lamp3 expression) (Fig. 2e, f) or, surprisingly, expression of markers of dysplastic regeneration (Scgb3a2 and Krt5) (Fig. 2d) despite low expression of these genes in culture. This evidence concerns the gene LAMP3 and infection.