BRSK2 and autism: BRSK2 is the only gene with multiple dnLGD variants in SPARK that reached genome-wide significance (p-value = 2.3 × 10−6 by one-sided exact Poisson test, <0.05/20,000 genes), although there was one individual in the Autism Sequencing Consortium (ASC) cohort7 with a dnLGD variant in BRSK2 (Table 2).