HGF and hepatocellular carcinoma: Because the model was developed to investigate the effect of the HGF pathway on HCC cells, the literature was mined rigorously to be able to calibrate the model by only using datasets from hepatocytes33 or HCC cell lines.30,34 Additionally, the hepatocyte data from a study that quantified the abundance of proteins from an extensive and calibrated mass spectrometry dataset in isolated mouse primary liver cells35 (hepatocyte, hepatic stellate cell, hepatic sinusoidal endothelial cell, Kupffer cell, and cholangiocyte) were used in this study.