Work on IgE in nasal polyps, specifically on Staphylococcus aureus enterotoxin-specific IgE (SE-IgE) pointed to the role of IgE28; in the meanwhile it was demonstrated that anti-IgE (omalizumab) can successfully be used in allergic as well as non-allergic type-2 inflammatory polyps.14 Here, IGHE is linked to Nasal polyposis.