In CRSwNP patients, tissue IgE levels were reported to relate to the severity of disease, the presence of comorbid asthma, and the presence of IgE to Staphylococcus aureus enterotoxins, while being independent of total serum IgE levels or allergy skin prick test responses.20, 21, 22 Until now, only in the dupilumab study data on biomarkers in nasal polyp tissue was reported.17 Here, IGHE is linked to chronic rhinosinusitis with nasal polyps.