H19 and cancer: To explore the clinical utility of the SNP genotypes, the interactive effects of H19 SNPs between rs4930101, rs11042170, rs2735970 and the environmental factors or clinical variables were determined by χ2 test and unconditional logistic regression adjusted by gender, ages, smoking status, and first history of cancer (Fig. 2b, Table 2 and Additional file 1: Table S2).