HDAC8 and myeloid neoplasm: We were intrigued by these interactions given the similar CRISPR screening scoring pattern of DCAF15 to the cohesin factors STAG2 and HDAC8 (Figure 2E); the shared roles of cohesin and CRL4 E3 ligases in DNA metabolism, organization, replication and repair (Uhlmann, 2016; O'Connell and Harper, 2007; Litwin et al., 2018); and the ability of cohesin mutations to dysregulate hematopoietic differentiation in myeloid malignancies (Mazumdar and Majeti, 2017).