CD2 and neoplasm: Single guide RNAs targeting multiple other tumor-immune synapse components were also enriched after NK-92 challenge, including NCR3LG1 (#26-ranked gene by MaGeCK score), the activating ligand for NKP30 on NK cells (Brandt et al., 2009); CD58 (#37), an adhesion molecule that binds CD2 (Selvaraj et al., 1987; Rölle et al., 2016); and CD84 (#80), a SLAM-related receptor that binds homotypically to promote activation and cytokine secretion in lymphocytes (Martin et al., 2001; Veillette, 2006; Wang et al., 2010).