Comparing these two tumor types directly shows a significant effect of genotype on staining distribution (Figure 5F), with BRAFV600E/PI3KαH1047R-driven tumors showing a strong decrease in AQP5+/LYZ+ double positive cells, with corresponding increases in each of the remaining classes of cells (AQP5+/LYZ-; AQP5-/LYZ+; and AQP5-/LYZ-). Here, AQP5 is linked to neoplasm.