BRAF and cancer: To model BRAFV600E driven cancers, we previously described BrafCA mice carrying a CRE-activated allele of Braf that expresses normal BRAF prior to CRE-mediated recombination, after which BRAFV637E (orthologous to human BRAFV600E and for simplicity henceforth referred to as BRAFV600E), is expressed from the endogenous chromosomal locus (Dankort et al., 2007).