PI3 and lung carcinoma: To address mechanism(s) of cooperation between BRAFV600E and PI3’-lipid signaling in lung cancer progression, lung tumorigenesis was initiated in BrafCAT or BrafCAT; Pik3calat-H1047R (Pik3caHR hereafter) mice (Figure 2A) and analyzed at 2, 6 or 12 weeks p.i. (Figure 2B, for detailed gating strategy see Figure 2—figure supplement 1A).