Ezrin protein (coded by EZR) is a member of the ERM (ezrin‐radixin‐moesin) protein family.13 Its function is to connect cell surface receptors, especially adhesion molecules and actin cytoskeleton.14, 15 Ezrin is mainly expressed at the top of cell surface and participates in maintaining the polarity of epithelial cells.16, 17, 18 Recent studies have found that ezrin participates in cells and bases interaction by regulating adhesion molecules and signal transduction pathways which may play an important role in the invasion and metastasis of cancer cells.19, 20. The gene discussed is MSN; the disease is cancer.