The SHANK3 gene is located on the long arm of chromosome 22 at position 22q13.3 and is the causative gene in Phelan–McDermid syndrome (PMS; Bonaglia et al., 2001, 2006; Dhar et al., 2010; Boccuto et al., 2013). This evidence concerns the gene SHANK3 and premenstrual tension.