ESR1 and autism: We sought to apply adult genetic rescue to our robust Shank3G Exon 21 mouse model of autism (Speed et al., 2015) by crossing the original Shank3G mouse line with another that expresses tamoxifen-inducible Cre recombinase under the CMV-chicken actin promotor, CAGGCre-ER (Hayashi and McMahon, 2002), abbreviated here as CreTam.