These include pathways related to oxidative stress, DNA damage and FXR/RXR activation, with the most significant alterations occurring in glutamate receptor signaling and degradation related pathways (“Glutamate degradation III via 4-aminobutyrate” and ‘Huntington's disease signaling’Figure 5C; p < 0.01). This evidence concerns the gene NR1H4 and Huntington disease.