Taking into account the already exposed role of miR-9 that orchestrates stemness and differentiation homeostasis, and its association to cancer vascularization in vitro [41], a potential role for this miRNA in physiological angiogenesis in vivo was proposed, after identification of mir-9 expression by means of in situ hybridization in NSCs in the SOX2+ proliferative zone of the developing human nervous tissue (cortical spheroids). The gene discussed is SOX2; the disease is cancer.