TET3 and cancer: In particular, exosomal miR-1246 and miR-1290 have been demonstrated to affect expression of target genes in receiving cell lines, particularly downregulating the expression of glioma-associated tumor suppressors PTEN and Tet Methylcytosine Dioxygenase 3 (TET3) and up-regulating cancer-related genes such as SERTA Domain Containing 1 (SERTAD1) and SEC61 Translocon Gamma Subunit (SEC61G) [14].