In 2014, Paudel et al. postulated that since the polyphenolics 6–6 bieckol and pholorofucofuroeckol A (59 and 60, Figure 17) inhibited p-ERK1/2 and p-JNK activation, these hold potential value for treating pulpitis and oral diseases [75]. This evidence concerns the gene MAPK8 and mouth disorder.