In 2015, Esther A. Guzmán et al. [109] reported microsclerodermin A (89, Figure 23), from the marine sponge Amphibleptula cf. madrepora, and this compound inhibited GSK3β and pancreatic cancer cell viability in vitro (IC50 = 2.4 μM). Here, GSK3B is linked to familial pancreatic carcinoma.