This improvement in hypertension could be due to the reported hypotensive effect of OA, probably by the modulation of the renin-angiotensin-aldosterone system and the synthesis of atrial natriuretic peptide [27,50], since Bachhav et al. [28] and Madlala et al. [29] showed that OA increased the quantity of urine sodium excreted [27,50]. The gene discussed is REN; the disease is Hypertension.