Based on a further functional classification, performed considering the therapeutic properties secretome should ideally possess to treat lung diseases caused by AAT-deficiency, we now report that about 30% (101 proteins) of the secreted proteins belong to four functional categories: protease/peptidase activity (46 proteins), protease/peptidase inhibitors (27 proteins), response to bacterium (46 proteins), and acute-phase response (12 proteins) (Figure 1, Table S1). The gene discussed is LAP3; the disease is hyperinsulinemic hypoglycemia, familial, 4.