In fact, the pathophysiology of PTSD involves many of the structures and neurocircuitry identified as key components in the development and/or perpetuation of addictive processes, such as amygdala hyperactivity, chronic activation of brain stress systems, and increased corticotropin-releasing factor (CRF) during acute drug-withdrawal; and the medial prefrontal cortex and its connections to the nucleus accumbens and ventral pallidum involved in animal models of craving and drug-induced reinstatement [3]. This evidence concerns the gene CRH and post-traumatic stress disorder.