MGMT and alpha thalassemia spectrum: Recent studies have proven that some molecular analysis of isocitrate dehydrogenase 1/2 (IDH 1/2), TP53, alpha thalassemia/mental retardation syndrome X-linked (ATRX), and o-6-methylguanine-DNA methyltransferase (MGMT) are associated with therapeutic efficacy and prognosis [3].