Notably, elevated serum levels of IFN-λ3 are significantly correlated with higher SLE disease activity and decreased complement level, and genetically, the IFNL3/4 SNP alleles that contain dysfunctional IFNL4 in combination with low production of IFN-λ3 seem to be risk factors for lupus nephritis [111]. Here, IFNL3 is linked to lupus nephritis.