Considering the involvement of sortilin genes in immunity mediated by macrophages, sorting of cellular proteins, as well as our previous study indicating the up-regulation of sortilin SORCS1 in a cell model expressing mHTT [11,12,17,18,19], here focused on investigating the association of sortilins with Huntington’s Disease using human and rat RNA-Seq datasets. This evidence concerns the gene SORT1 and juvenile Huntington disease.