However, the DESeq2 analysis was only detected as statistically significant, the difference in the expression levels of the SORL1 gene in the HD iPSC Consortium dataset (Figure 2C), suggesting a gene expression influence of mHTT on SORL1 similar to the trend detected previously in the AD for this receptor of Apolipoprotein E [42,43]. This evidence concerns the gene APOE and Alzheimer disease.