HLA-B and type 2 diabetes mellitus: By interrogating datasets analyzed for transcriptomic regulation and presence of SNPs associated with mHTT in specific genomic regions known to be involved with Type 1 and Type 2 Diabetes, we found that genes from the MHC/HLA locus, regarded as T1D markers [39], were down-regulated in human cells expressing mHTT in the HD iPSC Consortium dataset (HLA-B) (Figure 2C).