IFNAR1 and Zika virus infectious disease: To that end, IFNAR1-/- mice (seven mice per group) were immunized with 1 μg of sr-prM-E-mRNA ZIKV vaccine or sr-LUC-mRNA control using a prime-boost regimen with a two-week interval, as the older IFNAR1-/- mice (over three months old) were less susceptible to ZIKV infection [46].