Furthermore, Aβ interaction with Cyclin dependent kinase 5 (CDK5) induces phosphorylation of Drp1 at residue Ser-579, which leads cysteine-aspartic acid protease 3 (caspase 3) to be cleaved, executing indiscriminate cell apoptosis [61]; the result being AD pathology of neuronal death for example. Here, CDK5 is linked to Alzheimer disease.