Findings from in vitro studies from our lab [87] and in vivo studies (in APP/PS1 and CRND8 mice) by Baek et al. [43] and Wang et al. [44] indicate that Mdivi-1 is a Drp1 inhibitor and directly reduces mitochondrial fragmentation and improves overall mitochondrial and synaptic functions in AD. The gene discussed is DNM1L; the disease is Alzheimer disease.