After measuring the expression levels of epithelial and mesenchymal markers in tumor and adjacent nontumor tissues from 20 patients, Zhang and co-workers observed low expression of the epithelial markers E-cadherin and miR-200b, and high expression of the mesenchymal markers fibronectin and a-smooth muscle actin (α-SMA) in the tumor tissues [89]. This evidence concerns the gene ACTA1 and neoplasm.