Hydroxytyrosol can also correct metabolic deficiencies in diet-induced obesity in mice by correcting the aberrant expression of genes involved in hepatic lipogenesis (SREBP1, ACC, FAS, and Stearoyl-CoA desaturase-1), decreasing hepatic steatosis from induced obesity [22]. The gene discussed is FAS; the disease is obesity due to melanocortin 4 receptor deficiency.