BECN2 and neoplasm: Although a causal relationship between increased IL-6 production and accelerated tumor formation and lethality in BECN2+/− mice has not been established, the results are consistent with the conclusion that IL-6 is a key regulator of KSHV pathogenicity and provide clear evidence that Beclin-2 regulates KSHV GPCR-induced IL-6 levels in mice [125].