FOXO3 and neoplasm: Our observation is consistent with previous studies in which, metadherin has been shown to localise to nuclear speckles and to fine-tune many nuclear functions, including the regulation of expression of tumour promotor FOXO3a, the attenuation of promyelocytic leukaemia zinc finger protein (PLZF)-mediated transcriptional repression and the direct modulation of tumour-associated BCCIPα degradation [3,4,5,6].