Sam68 is associated with many hallmarks of cancer including epithelial-mesenchymal transition via stabilisation of the splicing factor SF2/ASF, cell cycle progression through Cyclin D1b, inhibition of apoptosis via BCL-X, cell migration through the cell surface protein CD44, and enhanced cell survival in response to DNA damage [21,22,23,24]. The gene discussed is KHDRBS1; the disease is cancer.