MAPT and Mental deterioration: A recent study revealed that individuals with subjective cognitive decline who reported poor performances on the PAL showed abnormal CSF p-Tau levels that were up to 10 years before [67], which supported the hypothesis that this measure reflects medial temporal lobe (hippocampal and parahippocampal) dysfunction due to neurofibrillary tangles deposition, as mirrored by the p-Tau CSF levels.