Some genes linked to PD have roles in endocytic pathways and autophagy, including LRRK2, VPS35 and PARK9. LRRK2 encodes the leucine-rich repeat kinase 2, a large multidomain protein released in association with exosomes involved in protein sorting and trafficking as well as autophagy [121,122]. The gene discussed is LRRK2; the disease is Parkinson disease.