Pharmacologic inhibition of de novo lipogenesis using the adenosine monophosphate-dependent protein kinase (AMPK)agonist 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) causes a similar anti-proliferative effect in EGFR-driven GBM models both in vitro and in vivo [99]. This evidence concerns the gene EGFR and glioblastoma.