The mechanisms underlying the role of the ATG16L1 WD domain in LAP remains elusive, but might be linked to the reported binding of the WD domain of ATG16L1 to Nucleotide-binding oligomerization domain-containing protein (NOD)-like receptors [211], Mediterranean fever (MEFV)/Tripartite motif (TRIM)-containing protein 20 (TRIM20) [212], Transmembrane protein 59 (TMEM59) [213] and Protein eva-1 homolog A (EVA1A)/TMEM166 [214]. The gene discussed is EVA1A; the disease is brucellosis.