Moreover, EpCAM and CD133 are expressed by microparticles, AnnexinV+ EpCAM+ CD147+ and AnnexinV+ EpCAM+ ASGPR1+ CD133+ tumor-associated microparticles (taMPs), in CCA liquid biopsy and have been proved to be a significant non-invasive diagnostic and prognostic tool [60]. This evidence concerns the gene ANXA5 and neoplasm.