CD274 and neoplasm: It has been shown that programmed death ligand-1 (PD-L1), one of the PD-1 ligands, binds to PD-1 of the T cells and initiates apoptosis of a tumor-specific T-cell leading to impair T-cell-mediated antitumor immune responses, and local immunosuppression, thus promoting tumor growth and metastasis [145,146,147].