On the other hand, CAF contribute to further recruit inflammatory cells, monocytes, macrophages, and endothelial cells to the tumor reactive stroma (TRS), through the secretion of a number of growth factors, such as VEGF and FGF, as well as a vast number of cytokines and chemokines, including MCP-1/CCL2, SDF-1 and CXCL-14. Here, CXCL12 is linked to neoplasm.