MKI67 and neoplasm: Figure 7E depicts representative immunohistochemistry for Ki67 and H & E staining of tumor of a control mouse and a tumor of ECPU-0001-treated mouse. The Ki67 expression as well as the mitotic count was significantly lower in the tumors of ECPU-0001-treated mice compared with control. ECPU-0001 treated A549 tumors showed significant reduction in tumorigenic marker Ki67 protein levels in immunohistochemistry study of tumor sections (Figure 7E).