NEFH and amyotrophic lateral sclerosis: Li and colleagues confirmed the presence of higher p-NfH levels both in plasma and in CSF of ALS patients in comparison to controls and they identified a cut-off level of 685 pg/ml for p-NfH in plasma (sensitivity of 80.39% and specificity of 73.81%), and the optimal cut-off value in CSF of 589 pg/mL, with a sensitivity of 82.35% and a specificity of 73.81% [7].