Upregulation of several inflammatory cytokines with tumorigenic potential, such as IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), and cyclooxygenase-2 (Cox-2), has been detected in many studies using either in vitro cultures or immunoassay techniques in CRC tissue samples [131,178]. This evidence concerns the gene PTGS2 and colorectal carcinoma.