Because HMGB1 has many biological functions and is associated with various signaling pathways, additional studies with other inhibitory molecules of HMGB1, such as ethyl pyruvate, anti-HMGB1 monoclonal antibodies, anti-RAGE antibodies, or recombinant A box peptides, are needed to further verify that HMGB1 is involved in the development of pathological dermal fibrosis such as keloids. This evidence concerns the gene HMGB1 and keloid.