PIK3CA and neoplasm: However, an exploratory analysis in patients with PIK3CA mutation (detected in circulating tumor DNA, ctDNA) described a benefit in terms of PFS from panPI3K inhibition (7.0 versus 3.2 months for the experimental and control arms, respectively, p not available), although patients without the PI3KCA mutation did not receive any additional benefit from buparlisib (6.8 months for both arms).