This research showed that the HaCaT cells after incubation with the anti-EGFR antibody-conjugated AuNPs can cause the complete destruction of the tumor at a laser density higher than 57 W/cm2 compared to control groups of two oral squamous carcinoma cell lines (HSC 313 (Hematopoietic stem cell) and HOC 3 (Cellosaurus cell line) ). Here, EGFR is linked to neoplasm.