Pro-apoptotic activity of miRNA in response to 5-fluorouracil has been reported in gastric cancer cell lines with down-regulation of the miR-204, which results in ectopic expression of Bcl-2; on the other hand, ectopic expression of miR-204 leads to down-regulation of Bcl-2 and determines colony formation and migration [158]. The gene discussed is BCL2; the disease is gastric cancer.