ITIH4 and Alzheimer disease: As EVs package and transport toxic proteins implicated in both AD and HIV (Aβ/tau and gp120/Tat, respectively) and given that Aβ is also elevated in plasma NDEs isolated from HIV patients, it may be reasonable to suggest that neuron-to-neuron exosomal transport of Aß and tau also contributes to AD-like pathology in HIV-positive subjects.