The downregulation of FUT1, and consequently of α(1,2) fucosylation, has been attributed, at least in pancreatic cancer, to constitutive Hif1α-mediated transcriptional suppression, suggesting that in pancreatic cancer, hypoxia suppresses cell surface α(1,2) fucosylation, which promotes cancer cell motility and migration [101]. The gene discussed is FUT1; the disease is familial pancreatic carcinoma.